Triazine derivatives



Patented Mar; 2,' i943 1 UNITED STATES, PATENT ,oFFics TRIAZINE DERIVATIVES Gaetano F. DAlelio, Pittsfleld, Mass, assignor to.

General Electric New York I No Drawing.

Company, a corporation of Application November 1, 1941 Serlai'No. 17,504

14 Claims. (301. 260-248) 1 v This invention relates to new chemical compounds and more particularly to triazine derivatives. The invention especially is concerned with the production of new and useful triazinyl suliamyl-carbocyclic-carbamyl-alkyl sulfides and triazinyl sulfamyl-carbocyclic-thiocarbamyl-alkyl sulfides. The triazine derivatives of this invention may be represented graphically by the following general formula:

In the above formula n represents an integer and is at least 1 and not more than 2, -Z representsa member of the class consisting of oxygen and sulfur, Y represents a divalent carbocyclic radical, and R represents a member of the class conatom.

Illustrative examples of radicals which R in the above formula may represent are: aliphatic- (e. 3., methyl, ethyl, propyl, isopropyl, allyl, butyl,

secondary butyl, isobutyl, butenyl, amyl, isoamyl,

hexyl, etc.) including cycloaiiphatic-(e. g., cyclo- 4 .pentyl, cyclopentenyl, cyclohexyl, cyclohexenyl,

cycloheptyl, etc.); aryl (e. g., phenyl, diphenyl or zenyl, naphthyl, etc.); aliphatic-substituted aryl (e. g., tolyl, xylyl, ethylphenyl, propylphenyl,

isopropylphenyl, allylphenyL' 2-butenylphenyl,

tertiary-butylphenyl, etc.); aryl-substituted ali-' and ever. there also may be produced in accordance withthe present invention chemical compounds such; for instance, as those represented by the general formulas: A

n -\N z BEN-4 5 I where n, Z, Y nd B. have the same meanings as above given with reference to Formula I.

Illustrative examples of divalent carbocyclic radicals which Y m Formulas I, n and in may pentenylene,- carbmethoxyphenylene,

phatic (e. g., benzyl, phenylethyl, phenylisopropyl, cinnamyl, etc.); and their homologues, as well as those groups with one or more of their hydrogen atoms substituted by, for example, a 7

halogen. Specific examples of halogeno-substituted hydrocarbon radicals are chloromethyl,

chloroethyl, chloropheiiyfifdichlorophenyl, chlorocyclohexyl, ethyl chlorophenyl, phenyl chloroethyl, bromoethyl, bromopropyl, bromotolyl, etc.,.

Preferably R in Formula I is hydrogen. How- (or thiocarbamyl) -alkyl sulfide. ganic sulfides are especially valuable in the represent are: arylene, e. g., phenylene, xenylene, naphthylene, etc.; alkarylene, e. g., 1,4-tolylene, para-(2,3-xylylene), etc.; cycloalkylene, e, g;. cyclopentylene, cyclohexylene, etc.; cycloalkenylene, e. g., cyclopentenylene, cyclohexenylene, etc.; and their homologues, as well as those divalent carbocyclic radicals with one or more of their hydrogen atoms replaced by a substituent, e. g.,

'halogeno, amino, acetyl, acetoxy, carbalkoxy, al-

koxy, aryloxy, hydroxy, allryl alkenyl, etc. spe-q ciflc examples of substituted divalent carbocylic 1 radicals are chlorophenylene, .bromophenylene.

chloronaphthylene, bromonaphthylene, bromo 1,4-tolylene, chlorocyclopentylene; chlorocycloethoxyphenyiene. acetophenylene. acetoxyphenylene, bromocyclopentylene; aminophenylene, phenoxyphenylene, hydroxyphenylene, methylphenylene (tolylene), allylphenylene, etc. Preferably Y is phenylene or methylphenylene.

The new compounds of this invention may be I used a chemotherapeutic agents and as intermediates in the preparation of derivatives thereof su h as ureido, hydrazino, acyl, carbamyl, amidine, etc., derivatives of the individual diamino triazinyl sulfamyl-carbocyclic-carbamyl These new 'orpreparation of synthetic resinous compositions. Thus, they may be condensed with, for instance, aldehydes, including polymeric aldehydes and aldehyde-addition products, to yield condensation products of particular utility in the plastics z-mercapto 4-(3' -butenylamino) and coating arts. Such-condensation products Para-.(sulionyl pentylamide) -tolyl-carbamyl cyclopentyl chloro methane Para (sulionyl 3 butenylamide) chlorotolyl- (butyD-carbamyl bromo methane Para- (sulionyl cyclohexylamide) -pheny1-(cyclopentyl) -thiocarbamyl chloro methane Para (sulfonyl phenylamide) phenyl-(chloroethyl) -carbamyl bromo methane 4- (sulfonyl chlorotolylamide) -cyc1ohexyl-(phencal triazine (s-triazine) and a suliamyl-carbocyclic-carbamyl (or triocarban yl) -alkyl halide.

in the presence of a hydrohalideacceptor. Illustrative examples of mercapto diamino s-triazines that may be used, depending upon the particular sulfide desired, are:

z-mercapto 4,6-diamino s-triazine (4-mercapto' 2,6-diamino s-triazine; B-mercapto 2,4- diamino s-triazlne) z-mercapto 4,6-di- (methylamino) s-triazine 2-mercapto 4,6-di- (anilino) s-triazine '2-mercapto ll-amino G-ethylamino s-triazine 2-mercapto 4,6-di-(propylamino) s-triazine I 2-mercapto 4-allylamino B-butylamino s-triazine Z-mercapto 4-isobutylamino fi-cyclopentylamino s-triazine fi-isopropylamino s-triazine 2-mercapto 4-pentylamino fi-cyclohexylamino s-triazine 2-mercapto 4-n-hexylamino fi-xenylamino s-triazine 2-mercapto 4-cyclohexenylamino G-naphthylamino s-triazine Z-mercapto 4-ch1orocyclopentylamino 6-toluido s-triazine Z-mercapto 4-bromotoluido 6-benzylamino s-triazine 2 -mercapto 4-phenylchloroethylamino 6-phenethylamino s-triazine yl) -carbamyl chloro methane 3 sultamyl cyclopentyl carbamyl tolyl chloro Ortho- (sulfonyl ,chloroethylamide) -phenyl-carb- 2-mercapto 4-chloroanilino fi-ethylphenylamino s-triazine z-mercapto 4-cyclohepthylamino G-isopropylphenylamino s-triazine 2-mercapto 4-isopropylanilino G-phenylpropylamino s-triazine Z-mercapto 4-dichloroanilino 6-chloroethy1amino s-triazine 2-mercapto 4-amlno 6-bromoethylamino s-triazine '2-mercapto 4-amino G-methylamino s-triazine 2-mercapto 4-aminoanilino fi-ethylphenylamino s-triazine 2-mercapto 4-amino 6-benzylamino s-triazine Illustrative examples of sulfamyl-c'arbocycliccarbamyl-alkyl halides and sulfamyl-carbocycllcthiocarbamyl-alkyl halides .that may be employed, depending upon the particular end-product sought, are:

Para-sulfamyl-phenyl-carbamyl chloro methane Alpha -(para' suli'amyl-phenyl-carbamyl) betachloro ethane Alpha-(meta-suliamyl phenyl-carbamyl) alphaamyl chloro methane i Meta -(sullonyl naphthylamide) phenyl carbamyl iodo methane Para-sulfamyl-phenyl carbamyl alpha-(bromophenyl) beta-chloro ethane Para- (sulfonyl isobutylphenylamide) phenyl- V carbamyl naphthyl chloro methane Various hydrohalide acceptors may be employed. I prefer to use a hydrohalide acceptor that will react with the mercapto triazine to form a-water-solu-ble salt. Examples of such acceptors are the alkali-metal hydroxides, e. g., sodium hydroxide, potassium hydroxide, etc. Additional examples of hydrohalide acceptors that may be used are other inorganic bases, e. g., calcium hydroxide, barium hydroxide, ammonium hydroxide, etc.; carbonates or inorganic bases, including the carbonates of alkali-metals; organic amines such as tertiary amines, e. g., trimethyl amine, triethyl amine, tributyl amine, pyridine, dimethyl aniline, quinoline, etc.; quaternary ammonium bases, e. g., tetramethyl ammonium hydroxide, etc.; and the like.

The reaction between the mercapto diamino s-triazlne and the sulfamyl-carbocyclic-carbamyl (or thiocarbamyl) -alkyl halide may be carried out in any suitable manner, but preferably is eflfected in the presence of a suitable solvent or mixture of solvents. Although various solvents and solvent mixtures may be employed, for economic reasons and because of their eminent suitability I prefer to use water or a mixture of water and alcohol. The reaction may b carried out under a variety of temperature and pressure conditions, for instance at normal or at elevated temperatures and at atmospheric, subatmospheric or super-atmospheric pressures. However, normal pressures and temperatures are preferred for convenience.

The above reaction may be represented by the following general equation:

IYIHR o y hydrohalide acceptor II II salt of 0-8-0 nRzrC-N R-Y-S OzNHR+ hydrohalide acceptor and n, Z, Y and B have the same meanings as givenabove with reference to Formula. I.

The new chemical compounds of this invention also may be prepared by effecting reaction between a halogenated diamino s-triazine and a sulfamyl-carbocyclic-carbamyl or thiocarbamyl mercapto alkane in the presence of a hydrohalide acceptor. This reaction may be carried out by any suitable means but preferably is effected in the presence oLan anhydrous solvent. An anhydrous solvent, e. g., alcohol, is

desirable because one of the reactants, namely, the halogenated diamino s-triazine, is hydrolyzl able. The other conditions of reaction may be the same as described above with reference to the first-mentioned method of preparation.

Illustrative examples of halogenated diamino' s-triazines that may be used, depending on the end-product desired, are:

'2-brorno 4,6-diamino s-triazine 2-chloro' 4,6-diamino s-triazine.

' 2-chloro 4-bromotoluido' G-benzylainino, s-triazine 2-chloro 4-phenylchloroethylamino G-phenethylamino-s-triazine 2-chloro i-aminoanilino 6-ethylanilino s-triazine 2-chloro 4-chlorocycloheptylaminc G-isopropylphenylamlno s-triazine' '2-chloro i-isopropylanilino S-phenylpropylamino s-ti'iazine a Alpha- [para- (sulfonyl Para-(sulfonyl mercapto ethane 2,312,692 I Y a 3 Alpha-(parav-suliamyl-phenyl-carbamyl) betamercapto ethane Alpha-(meta-sulfamyl-phenyl-carbamyl) alpha mercapto ethane methylamine) -'phen ylthiocarbamyll 'alpha-mercapto pen'tane Ortho sulfamyl- (methyl) -carbamyl mercapto methane Alpha -.(4-sulfamyl naphthyl [ll carbamyl) 1 beta mercapto 3'-butene Alpha- (para-sulfamyl-chlorophenyl ,carbamyl) alpha-ethyl beta-phenyl beta-mercapto ethane Para-(suli'onyl pentylamide) -tolyl-carbamyl cyclopentyl mercaptomethane (butyl) -carbamyl mercapto methane Para-(sulfonyl cyclohexylamide) phenyl-cyclo pentyD-thiocarbamyl mercaptc methane Para (sulfonyl phenylamide)-phenyl-(chloroi,2" ethyD-carbamyI mercapto methane 4-(sulfony'l chlorotolylamide) -cyclohexyl-(phen yl) -carbamyl mercapto methane Alpha [para (sulionyl propylphenylamlde) phenyl- (bromophenyl) -thiocarbamyll Alpha [para (sulfonyl amide) phenyl (xenyl) carbamyl] alphachlorotolyl beta-mercapto ethane Meta (suli'onyl naphthylamide) phenyl carbamyl mercapto methane Ortho- (sulfdhyl chloroethylamide); -phenyl-carbamyl mercapto methane Para-sulfamyl-phenyl-carbamyl alpha-(brcmophenyl) beta-mercapto methane tPara-(sillfonyl butylphenylamlde) -phenyl-carbamyl naphthyl mercapto methane Alpha- (suli'onyl isopropylamide) -cyclohexenyl- (methyl) -carbamyll alpha, betadi-(phenyl)- alpha-methyl \beta-chlorobutyl beta-mercapto ethane The hydrohalide acceptor may be the same as described above with reference to the first-named method of preparing the compounds of this invention.

The general reaction for this alternative "method oi preparing my new chemical compounds is illustrated by the following equation:

2 z v 7 4 mm of hydrohalids acceptor arm-('2 8-8-O.Rg.g-NB-YS0,NHR

2-bromo 4-dichloroa'nilino d-chloroethylaminc vs-triazine 2-iodo 4-amino fi-brom'oethylamlno s-triazine z-iodo, 4,6-diamino s-tria'zine Para-sulfamyl-phenyl-carbamyl mercapto methane and 1:, Z, Y and B have the same meanings as given above with reference to. Formula I.

In order that those skilled in the art better may understand how the present invention may .-be carried into effect, the i'ollowing illustrative examples are given. All parts are by weight.

example illustrates the preparation 01'' 7i 4,6Z-diamino s-triazinyl-il para -suli amyl-phenyl- 3 butenylamide) chlorotolylbetaphenylchloroethyl- In the above equation x represents,halogen,

I vrr manner as described under Example 1 with the exception that, instead of para-suliamyl-phenylcarbamyl chloro methane, an equivalent amount of para-sulfamyl-tolyl-carbamyl chloro methane is employed. Y

Other examples of the new chemical compounds of this invention are shown below:

4,6-diamino s-triazinyl-z beta-(para-sullamyl-phenyl-thiocarbamylethyl) sulfide carbamyl-methyl sulfide, the formula for I which is: i, p

G \"I NH I Y a i i. O 5 moHN-c c-s-0H,cm-c-NH-Os 0mm mN-( I )SCHz( JNHOSOINHz N v \N/ I 4, G-di-(methylamin o) s-triuinyl-Z beta-(parasulfamyl-phenyl- I, y lo I carbamyl-ethyl) sulfide This compound also may be named 2,6-diamino s-triazinyl-4 para-sulfamyl-phenyl-carbamyl-, x 7 methyl sulfide or 2,4-diamino s-triazinyl-B para- 4 Naomi sulfamyl-phenyl-carbamyl methyl sulfide. v i V Parts 'f El I ISOINHI Thioammeline' t 97.7. p

Sodium hydroxide 28.1 /C S EH C NH O Para sulfamyl phenyl carbamyl chloro N i methane "f 7' 4,6-di-(am'lino)s-triazinyl-2aphii-glnggarsullamyl-phenyl-mrbamyl t 5 The thioammeline was dissolved in 600 parts 8 y a water containing the stated amount of sodium XI hydroxide. The mixture was heated on a steam plate until solution was effected. To theclear, 1 hot solution the stated amount of para-sulfamyl- 2K phenyl-carbamyl chloro methane was added with v N N s stirring over a period of minutes. The result- HCIHN43 g g O ing solution was allowed to stand at room temperature for several days; The precipitate com- N prising 4,6-diamino s-triazinyl-2 para-sulfamyl- 6 ml m i 1231 h K n" l phenyl-carbamyl-methyl sulfide was filtered from i g zf g the solution and recrystallized from water. An methyhmlde) p my mom amylpen yl] additional amount. of sulfide was recovered from XII the filtrate. The-impure sulfides were washed NHC'HT free of water-soluble salts.

Eatample 2 l I H SOINHI V 4,6 diamino s triazinyl 2 para sulfamylm g C S CH"CTN(CH) phenyl-thiocarbamyl-methyl sulfide is produced Q N in the same manner as described under Example 1 with the exception that, instead of para-sulci?2;"i1&?$3 famyl-phenyl-carbamyl chloro methane, an a a y y equivalent amount of para-sulfamyl-phenylx111 4 thiocarbamyl chloro methane is employed. NHCH QH:CH

Example 3 N N 4,6-diamino s-triazinyl-2 para-sulfamyl-tolyl- I ll ll carbamyl-methyl sulfide is produced in the same Baum-C C"S CH Clare-NH S 4-al1ylamino dbutylamino s-trlazinyl-Z beta-(4J-suliamyl-naphthyl- V [1']-carbamyl-3-buteny1) sulfide NHCHrCHrCH=CHz 4-(3-butenylamino) G-propylamino s-triazinyl-Z para-(sullonyl amylamide)-tolyl-carbamyl-eyclopentyl-methyl sulfide 4-sminoanilino o-ethylsnllino s-triuinYM meta-(sulfonyl naphthyl smide)-phonyl-carbamy methyl sulfide xxIv NHC1HuCl' o BOINHO2H4C1 i-(chlorocyclohe tylamino) apro ylphenylamino s-trlN-lnyl-2 meta- (sulionyl chloroethylamide)- lienyl-uirbuuiyl-methyl sulfide NHCeHACs 'I i-propylanilino fi-phenylptollylamino s-trlazlnyl-2 beta-[paras 1 suliamyl-phenyl-carbamyl-(alphs-bromophenyD-ethyl]sulfide N 0 (i t S-CH- -NH SOsNHC|H4C4H| O N (lioHr 4-dichloroanilino B-chlorethglamino s-triazinyl-2 para- (sulfonyl butyl henylaml e) phenyl carbamyl -(naphthyl) -methyl' suli de CIHICIHIN ('1 4-bromoethy1amino B-amino s-trlasinylfl xx phenyl-carbomyl-ohlombutyi) C sN-L N 4,6-dismino l-triazin 1-2 (sulionyl pro ylamlde)-cyclohexenyl- (methgD-carbemyl-al ha, beta-diphcn?l alphrmothyl betachloro utyD-ethyl do XXIX =NH I I c rim-c: A-s-cmQm-E-NHG-MMI.

4,6-diamino s-triaainyl-Z bew Wiamyl-tolyl-carbamyl-ethyl) 4,6-diamino s-trluinyM para-suliamyl-tolyl-thiombemylmethyl sulfide XXXI NH:

BOsNH:

4 o-diamino s-trlssin 1-2 meta-sultan l-phuyl-corbam lmethyl sulfide y XXIII NH:

BONE:

4 os-ti'iuin l-icrtho-culfam lion i-carbem i- ,O-diamin r l 71: r r

In a manner similar to that described above with particular reference to the diamino .ll(-NHR)2] s-triazinyl sulfamyl-carbocycliccarbamyl-alkyl sulfides, corresponding derivatives of the asymmetrical and 'vicinal triazines may be prepared. It also will be understood by those skilled in the art from the foregoing description of the preparation of a triazine monosulfide 1o 7 A I i \N C s that similar compounds may be prepared in which two or three sulfur atoms are attached directly to a carbon atom of the triazine nucleus, thus:

What I claim as new and desire to secure by Letters Patent of the United States is:

1. Chemical compounds corresponding to the general formula N z 5s a. armc-s-canr -nn r-somna where n represents an integer and is at least 1 p and not more than 2, z represents a member of the class consisting of oxygen and sulfur, Y rep- .0 resents a divalent carbocyclic radical, and R represents a member or the class consisting of hydrogen and monovalent hydrocarbon and halohydrocarbon radicals.

5. Chemical compounds corresponding to the general formula 1 arm-g c-s-cm-E-Nm-Y-somm where Y represents a divalent carbocyclic radical. 7s and It represents a member of the class consist- -6. A-diamino s-triazinyl suliamyl-carbocyclic carbamyl-methyl sulfide.

7. A diamino s-triazinyl sulfamyl-phenylcarbam'yl-methyl sulfide.

8. Diamino s-triazinyl para-suliamyl-phenylcarbamyl-methyl sulfide.

9. A diamino s-triazinyl suliamyl-tolyl -carbarnyl-methyl sulfide.

. 10. Adlamino s-triazinyl sulfamyl-carbocyclicthiocarbamyl-methyl sulfide.

11. A diamino s-triazinyl suliamyl-phenylthiocarbamyl-methyl sulfide.

12. The method or preparing chemical compounds correspondingto the general formula BEN-o SC.R|. --NRYB0NHR where 1|. represents an integer and is at least 1 and not more than 2, Z represents a member 0'! the class consisting of ozwgen and sulfur, Y represents a divalent carbocyclic radical, and R represents a member of the class consisting of hydrogen and monovalent hydrocarbon and halo-hydrocarbon radicals, said method comprising efiecting reaction. in the presence of a hydrohalide acceptor, between (1) a mercapto 5 triazine corresponding to the general formula NHR where R has the meaning above given, and (2) ya halide corresponding to the general iormula X C.R;..- NR -YSO,NHR where X represents halogen, and 11-, Z, Y and R. have the meanings above given.

13. "A method as in claim 12 wherein the hy drohalide acceptor is an alkali-metal hydroxide. 14. A method 01 preparing diamino s-triazinyl para-suliamyl-phenyl-carbamyl-methyl sulfide which comprises effecting reaction, in the pres- 25 ence of a hydrohalide acceptor, between thioammeline and para-sulfamyl-phenyl-carbamyl chloro methane.

GAEIANO F. DALELIO.

Certificate of Correction.

Patent No. 2,312,692. v March 2, 1943.

- GAETANO ,F.DALELIO It is hereby certified that errors appear. in the printed specification of the above numbered patent requiring correction as follows: Page 1, rst column, line 42, for

zenyl read wenyl; and second column, l1nes 5 to ,8 inclusive, for that portion of the formula reading 7 mm NHR 0 read G I! I II I page 2, first column, lines 3 and 4, for Nov. 11, 1941 read Nov. 1, 1941; line 7, for synethetic read synthetic; line 14, for triocarbamyl read thiocarbam'yl; line 45, for 4-cyclohepthylamino read 4-cycloheptylam'ino; and second column, line 36, for or after carbonates read of; page 3, first column, line 68, after 2-iodo strike out the comma; and second column, line 5, for methylamine read methylam'ide; line 10, for beta mercapto read beta-mercapto; line 17, for phenyl-cyclo read phenyl-(cyclo-; page 4, second column, line 20-, Fomiula X,'after carbamyl insert a hyphen; line 74, Formula XV, for 4-(3-butenylamino) read 4-(3-butenylamino) page 5, Formula XVIII, for the portion thereof reading SO HNC I-L read SO NHG,H Formula XIX, name of compound appearing 'belowsaid formula, for (4'sulfonyl read (4-sulf0nyl; Formula XX, bottom line thereof, for- C N CH read C,H OH Formula XXI, for a page 6, first column, lines 6-7, Formula XXIV, for 5 ll CNH-- line 17, Formula XXV, for para-2 read para; and that the said Letters Patent should be read with these corrections therein that the same mayconform to the record of the case in the Patent Oflice.

Signed and sealed this 8th day of June, A. D.. 1943.

[smL] HENRY VAN ARSDALE,

Acting Commissioner of Patents. 

